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Twclinical tials w conductd with ACTOS in combination with insulin. Both tials includd patints with typ 2 diabts on insulin, ith alon in combination with anoth antidiabtic agnt. All oth antidiabtic agnts w withdawn pitstating study tatmnt. In th ist tial, 566 patints w andomizd tciv ith 15 mg 30 mg ACTOS placbonc daily 16 wks in addition tthi insulin gimn. Tatmnt with ACTOS as add-on tinsulin poducd statistically signiicant impovmnts in HbA1c and PG at ndpoint compad tplacbadd-on tinsulin (s Tabl 24). Th man daily insulin dos at baslin in ach tatmnt goup was appoximatly 70 units. Th majoity patints (75% ovall, 86% tatd with placbo, 77% tatd with ACTOS 15 mg, and 61% tatd with ACTOS 30 mg) had nchang in thi daily insulin dos om baslin tth inal study visit. Th man chang om baslin in daily dos insulin (including patints with ninsulin dos modiications) was -3 units in th patints tatd with ACTOS 15 mg, -8 units in th patints tatd with ACTOS 30 mg, and -1 unit in patints tatd with placbo.

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