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32Antunes CMStrolley PDRosenshein NBDavies JLTonascia JABrown CBurnett LRutledge APokempner MGarcia REndometrial cancer and estrogen useReport of a large case-control studyN Engl J Med 30019799-13.

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1Accelerated prothrombin timepartial thromboplastin timeand platelet aggregation timeincreased platelet countincreased factors IIVII antigenVIII antigenVIII coagulant activityIXXXIIVII-X complexII-VII-X complexand beta-thromboglobulindecreased levels of anti-factor Xa and antithrombin IIIdecreased antithrombin III activityincreased levels of fibrinogen and fibrinogen activityincreased plasminogen antigen and activity2Increased thyroid-binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT 4 levelsby column or by radioimmunoassayor T 3 levels by radioimmunoassayT 3 resin uptake is decreasedreflecting the elevated TBGFree T 4 and free T 3 concentrations are unalteredPatients on thyroid replacement therapy may require higher doses of thyroid hormone3Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroids and sex steroidsrespectivelyFree hormone concentrations may be decreasedOther plasma proteins may be increasedangiotensinogen/renin substratealpha-1-antitrypsinceruloplasmin4Increased plasma HDL and HDL 2 subfraction concentrationsreduced LDL cholesterol concentrationincreased triglycerides levels5Impaired glucose tolerance6Reduced response to metyrapone test.

41Molitch MEOill POdell WDMassive hyperlipemia during estrogen therapyJAMA 2271974522-5.

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