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Exelon doesn t anticipate any immediate staffing changes to the plant, which employs approximately 600 people, officials said.

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In generaladverse reactions were less frequent later in the course of treatment.

Mild to moderate Alzheimer’s DiseaseOralInitial dose1.5 mg orally twice a day with morning and evening mealsMaintenance doseAfter a minimum of two weeks of treatmentif the initial dosage is well toleratedit may be increased to 3 mg twice a daySubsequent increases to 4.5 mg and 6 mg twice a day should be attempted only after a minimum of 2 weeks at the previous dosageTransdermalInitial Dose4.6 mg/24 hour transdermal patch applied to the skin once daily Maintenance DoseAfter a minimum of four weeks of treatment and if well toleratedthe dose of the patch can be increased to 9.5 mg/24 hours for as long as this dose is beneficialThe dose can then be increased to 13.3 mg/24 hoursMaximum Dose13.3 mg24 hour transdermal patch applied to skin dailyHigher doses confer no appreciable additional benefitand are associated with significant increase in the incidence of adverse eventsCommentApply once a dayPress down firmly for 30 seconds until edges stick wellUse upper or lower back as the site of applicationDo not apply to skin area where creamlotionpowder has been recently appliedDo not apply to skin that is redirritatedor cutWear one patch at a timeChange site of application dailydo not apply a new patch to same location for at least 14 daysMay wear patch during bathingbut avoid long exposure to external heat sources.

Figure 5 illustrates the cumulative percentages of patients from each of the 3 treatment groups who had attained at least the measure of improvement in ADAS-cog score shown on the x-axisSimilar to the U.S26-week studythe curves demonstrate that both patients assigned to EXELON and placebo have a wide range of responsesbut that the 6 mg to 12 mg per day EXELON group is more likely to show the greater improvements.

If Exelon Patch is working as part of your loved one’s treatment plantalk to their doctor about staying with a brand-name medicationOnly your loved one’s doctor can determine whether Exelon Patch is right for them.

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